Exosomes

Once considered a niche area of cellular research, exosomes—extracellular vesicles (EVs) packed with proteins and gene-regulating RNA—might represent the next generation of biotherapeutic delivery mechanisms. Consequently, interest in exosomes is rapidly expanding.

These EVs have already shown promise for use in diagnosing, monitoring and even treating a range of conditions, including some forms of cancer, as well as cardiopulmonary and neurodegenerative disorders. Developing exosome-based nanomedicines, however, is not without significant challenges. Chief among these are successfully detecting, isolating, characterizing and purifying the vast array of exosomes produced by various types of human cells.

Still, these tiniest of vesicles (typically 30–200 nm in diameter) could ultimately help us take an enormous leap forward in modern medicine. Learn more:

Products for Biotherapeutic Production

Centrifuge Analytical Ultracentrifuge Optima Auc

Optima Analytical Ultracentrifuge

• Quick-turn optics for using absorbance & interference
• Remote setup and viewing for simplified access to instrument details, live data, and data export
• Faster absorbance scan rate and improved radial resolution enhance discrimination of similar components, such as viral particle capsids 
• Greater wavelength precision yields more reliable results
• Includes multi-wavelength (MWL) detector

Avanti JXN 26 high speed centrifuge

Avanti JXN-26 Series High Performance

• Perfect for shared labs or GMP environments
• GMP supporting features and BioSafe** options
• Quickly isolate cells
• Rapidly remove debris

Avanti-JXN 30 high-speed centrifuge

Avanti JXN-30 Series High Performance

• Widespread use in biologics production
• Personalized user profile
• Control access to centrifuge in a multi-user environment
• Max speed/g-force: 30,000 rpm/110,500 x g
• Isolate microparticles fast and efficiently.

Optima MAX-XP Ultracentrifuge

Optima MAX-XP Ultracentrifuge

• Password-controlled security features
• This tabletop reaches speeds up to 150,000 RPM
• Remote monitoring and control 
• BioSafety** options
• Ideal for exosome purification 

Optima XPN ultracentrifuge

Optima XPN Ultracentrifuge

 • Multi-layered BioSafety features 
• Software supports 21 CFR Part 11 Compliance
• Remote monitoring and control 
• Networking capability 
• Customizable security and tracking features
• Proprietary software optimizes protocols
Avanti J-15 benchtop centrifuge

Avanti J-15 High Performance

• UHT produces cleaner supernatants and higher yield pellets in less time
• Detects imbalance within 30 sec of start
• Optimized bench space with truly ventilated model
• Utilizes laboratory air to effectively maintain sample temperature
• BioCertified*** aerosolve canisters available 

carousel of the Vi-CELL BLU Cell Viability Analyzer

Vi-CELL BLU Cell Viability/Counting Analyzer

 • Accurate and reproducible results assured by multiple external standards
• Facilitates your ability to be compliant with IQ/OQ Fully automated sample preparation
• Cleanroom compatible
• Key system components facilitate 21 CFR Part 11 compliance
Quick-Seal Round-Top Polypropylene Tube

Quick-Seal Tubes

 • Eliminates most of the steps involved in capping ultracentrifuge tubes and cuts handling time in half
• Filled tube is heat-sealed using a hand-held sealer
• Ideal  for sample storage and for working with radioactive or pathogenic samples
• Available in dome-top and bell-top designs 
Sterile + Certified Free Round Bottom Polypropylene centrifugation Tube box

Certified Free, Ultracentrifuge Tubes

• Exhibits no detectable DNA, DNase, RNase, PCR inhibitors, or endotoxins*
• Ideal for Genomics, Exosomes, and Proteomics workflows
• Prevents sample degradation and contamination
• Double-bagged to prevent contamination during  cleanroom transfer
• Improve QC data quality

1L HarvestLine System Liners Kit

HarvestLine System Liners

 • Reduce biologics exposure
• Minimize sample contamination risks
• Save freezer space
• Optimize workflows
• Available sizes: 1L, 750mL, and 500mL 

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Content and Resources

Optima MAX Series - Tabletop Ultracentrifuge A brief but comprehensive review of the features that make the Optima MAX tabletop ultracentrifuge a versatile, easy-to-use instrument designed to meet the challenges of today's research environment
Avanti JXN Series High Performance Centrifuge: Introduction A brief introduction to the Avanti JXN series of high-performance centrifuges
Avanti JXN High Performance Centrifuge - Bioproduction A brief overview of features that make the Avanti JXN line of centrifuges a good choice for bioproduction needs
Introduction to AUC - an Analytical Ultracentrifuge A brief but informative visual demonstration of the process of analytical ultracentrifugation, which enables live monitoring of macromolecules in solution under native, biologically relevant conditions
Avanti J-26S Versatility A brief overview of features that make the J-26S series of high-performance centrifuges so versatile
*Based on sample results below detectable limits.
**BioSafety are terms intended to describe the enhanced biocontainment features of our products.
***BioCertified is a term used to describe our products which have been tested and validated to demonstrate containment of microbiological aerosols by an independent, third-party facility (Health Protection Agency, Porton Down, UK or USAMRIID, Ft. Detrick, MD, USA). Improper use or maintenance may affect seal integrity and, thus, containment.